Create disorder in; muddle or ruin. For example, On rainy days the children really mess up the house, or He had a way of messing up his own business. [c. 1900]
Make a mistake, especially from nervousness or confusion, as in He messed up and took the wrong dossier to the meeting, or Jill swore she would never mess up again. [Colloquial; early 1900s]
Beat up, manhandle, as in Joe got messed up in a barroom brawl. [Slang; early 1900s]